Figure 2.

Mechanism of action of anti-HER2 ADCs. The figure schematizes the different steps involved in the action of anti-HER2 ADCs, which include: (step 1) binding of the ADC to HER2, (step 2) internalization of the ADC-HER2 complex, (step 3) lysosomal degradation of the ADC, and (step 4) release of the payloads to the cytosolic compartment. DM1 inhibits microtubule polymerization by targeting tubulin, while DXd moves to the nucleus causing DNA damage by targeting topoisomerase I.