Figure 1.

(A). Reaction scheme for radiolabelling with ¹²⁵I in the presence of an oxidant to a precursor (olaparib derivative) for obtaining [¹²⁵I]-PARPi-01. (B). Blocking experiment: Co-treatment of [¹²⁵I]-PARPi-01 (1 MBq/10⁶ cells; 1 nM) with/without 100 nM olaparib and uptake measured by gamma counter 1 h post incubation. Statistical significance was tested using t-test (n = 3) (* p < 0.05).