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. 2022 Jan 3;5(1):8–19. doi: 10.1021/acsptsci.1c00182

Figure 6.

Figure 6

NP HTRF assay confirmation of remdesivir inhibition of SARS-CoV-2 replication. The TR-FRET ratio for SARS-CoV-2 NP in Vero E6 infected with the SARS-CoV-2 USA-WA1/2020 strain at an MOI of 0.009 based on protocol (A) for 24 h (B). Remdesivir was added at a starting concentration of 100 μM and serially diluted 1:3. The standard curve (C) using recombinant SARS-CoV-2 NP. Plates were incubated with NP HTRF reagents for 1 h at RT or O/N at 4 °C. N = 3 wells in a half-area 96-well plate. Error bars indicate S.D.