Table 3.
Statistical association of EpCAM/CD166 phenotypes expression with clinicopathological parameters in colorectal cancer specimens (Pearson χ2). The bold values are statistically significant
| Variables | Total no. (%) | EpCAM/CD166 phenotype expression, no. (%) | P value | |||
|---|---|---|---|---|---|---|
| EpCAMLow/CD166Low | EpCAMHigh/CD166Low | EpCAMLow/CD166High | EpCAMHigh/CD166High | |||
| Mean age years | ||||||
| 60 ≥ | 184 (51) | 32 (17.5) | 71 (38.5) | 29 (16) | 52 (28) | 0.2 |
| 60 < | 176 (49) | 45 (25.5) | 56 (32) | 29 (16.5) | 46 (26) | |
| Gender | ||||||
| Male | 192 (53.5) | 40 (21) | 64 (33.5) | 35 (18) | 53 (27.5) | 0.65 |
| Female | 167 (46.5) | 36 (21.5) | 63 (37.5) | 23 (14) | 45 (27) | |
| Tumor size (cm) | ||||||
| 5 ≥ | 239 (67) | 47 (20) | 90 (37.5) | 36 (15) | 66 (27.5) | 0.26 |
| 5 < | 117 (33) | 30 (25.5) | 33 (28) | 22 (19) | 32 (27.5) | |
| TNM stage | ||||||
| I | 59 (16.5) | 12 (20) | 28 (47.5) | 5 (8.5) | 14 (24) | 0.03 |
| IIA | 139 (39) | 28 (20) | 42 (30) | 16 (11.5) | 53 (38.5) | |
| IIB | 19 (6) | 6 (31.5) | 5 (26) | 3 (16) | 5 (26) | |
| IIIA | 54 (15) | 8 (15) | 18 (33) | 18 (33) | 10 (19) | |
| IIIB | 49 (14) | 13 (26.5) | 20 (41) | 11 (22.5) | 5 (10) | |
| IIIC | 11 (3) | 5 (45.5) | 2 (18) | 1 (9) | 3 (27.5) | |
| IVA | 19 (5.5) | 5 (26) | 7 (37.5) | 2 (10.5) | 5 (26) | |
| Tumor location | ||||||
| Cecum | 60 (19) | 18 (30) | 16 (27) | 9 (15) | 17 (28) | 0.05 |
| Sigmoid | 113 (34) | 16 (14) | 46 (41) | 14 (12.5) | 37 (32.5) | |
| Rectom | 73 (22) | 20 (27.5) | 27 (37) | 17 (23.5) | 9 (12) | |
| Colon ascending | 28 (8.5) | 8 (29) | 11 (39) | 1 (3) | 8 (29) | |
| Colon transvers | 27 (8) | 2 (7.5) | 10 (37) | 7 (26) | 8 (29.5) | |
| Colon descending | 11 (3.5) | 2 (19) | 3 (27) | 3 (27) | 3 (27) | |
| Rectosigmoid | 17 (5) | 6 (35) | 5 (29.5) | 1 (6) | 5 (29.5) | |
| Tumor differentiation | ||||||
| Well | 132 (37) | 25 (19) | 54 (41) | 13 (10) | 40 (30) | 0.05 |
| Moderate/poor | 225 (63) | 52 (23) | 72 (32) | 45 (20) | 56 (25) | |
| Distant metastasis | ||||||
| Positive | 23 (6.5) | 4 (17.5) | 11 (48) | 3 (13) | 5 (21.5) | 0.65 |
| Negative | 326 (93.5) | 70 (21.5) | 113 (35) | 54 (16.5) | 89 (27) | |
| Neural invasion | ||||||
| Positive | 57 (16.5) | 22 (39) | 14 (25) | 10 (17) | 11 (19) | 0.01 |
| Negative | 294 (83.5) | 53 (18) | 110 (37.5) | 47 (16) | 84 (28.5) | |
| Vascular invasion | ||||||
| Positive | 45 (13) | 12 (27) | 14 (31) | 11 (24.5) | 8 (17.5) | 0.18 |
| Negative | 308 (87) | 63 (20.5) | 112 (36.5) | 46 (15) | 87 (28) | |
| Lymph node invasion | ||||||
| Positive | 126 (35) | 29 (23) | 44 (35) | 29 (23) | 24 (19) | 0.01 |
| Negative | 233 (65) | 47 (20) | 83 (35.5) | 29 (12.5) | 74 (32) | |