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. 2022 Jan 10;10:5. doi: 10.1186/s40478-021-01308-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — (a) Overview of cases with initial histological diagnosis PXA (histPXA) and assignment to classes via the brain tumor classifier. For more information about methylation classes please refer to our previous publication [2] (b) Spectrum of histological diagnoses of cases assigned to methylation class PXA (mcPXA; GBM = glioblastoma and gliosarcoma E-GBM = epithelioid glioblastoma, Glioma = other glial tumors including diffuse astrocytoma, oligodendroglioma, ependymoma, pilocytic astrocytoma, astroblastoma and glioma without further specification, GG = ganglioglioma and GNT = other glioneuronal tumors, PXA = pleomorphic xanthoastrocytoma and anaplastic pleomorphic xanthoastrocytoma; other = included further rare diagnoses like PNET, meningioma, ATRT, FCD, etc. A comprehensive list of abbreviations is provided in the Additional file 6