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. 2022 Jan 10;10:5. doi: 10.1186/s40478-021-01308-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Overall survival (Kaplan–Meier curve) of patients in cohort mcPXA stratified after CNS WHO grade (a) and pTERT status (b, c). (b) includes tumors classified via the brain tumor classifier and (c) includes tumors classified via tSNE. pTERT mutant mcPXA revealed significantly worse overall survival compared to wild type mcPXA (log rank P* < 0.0001). CNS WHO grade did not show any prognostic significance in mcPXAs (log rank P > 0.05)