Fig. 3.

YES1 depletion decreases cisplatin sensitivity in ovarian cancer cell lines. A and B YES1 was significantly upregulated at both the mRNA level (A) and protein level (B) in A2780-DDP and SKOV3-DDP cell lines compared with A2780 and SKOV3 cells, respectively. C and D YES1 mRNA levels (C) and protein expression (D) were reduced significantly after siRNA targeting YES1 transfection. E Yes1 knockdown increases cisplatin sensitivity in A2780-DDP and SKOV3-DDP cell lines. F and G YES1 mRNA levels (F) and protein expression (G) were increased significantly after YES1-OE vector transfection. H Yes1 overexpression increases cisplatin resistance in A2780 and SKOV3 cells. For comparisons, Student’s t test was performed; *p < 0.05, **p < 0.01