Table 6.

Studies comparing anterior cervical discectomy and fusion versus cervical disc arthroplasty

Study	Design	Country	n (CDA/ACDF)	Age (years)
Porchet and Metcalf (2004)[41]	RCT	Switzerland	27/28	44
Mummaneni et al. (2007), Burkus et al. (2010, 2014), Gornet et al. (2019)[42,43,44,45]	RCT	USA	275/265	43.5
Nabhan et al. (2007, 2011)[46,47]	RCT	Germany	20/21	44
Murrey et al. (2008, 2009), Delamarter et al. (2010), Kelly et al. (2011), Kesman et al. (2012), Zigler et al. (2013), Zigler et al. (2013)[48,49,50,51,52,53,54]	RCT	USA	103/106	42.5
Sasso et al. (2007, 2008, 2011)[55,56,57]	RCT	USA	242/241	44.7
Riina et al. (2008)[58]	RCT	USA	10/9	39
Riew et al. (2008)[59]	RCT	USA	59/52	45
Heller et al. (2009)[60]	RCT	USA	106/93	44.5
Cheng et al. (2009, 2011)[61,62]	RCT	USA	41/42	47.2
Mcafee et al. (2010)[63]	RCT	USA	151/100	44.5
Coric et al. (2011)[64]	RCT	USA	136/139	44
Zhang et al. (2012)[65]	RCT	China	60/60	44.8/45.6
Vaccaro et al. (2013)[66]	RCT	USA	236/144	44
Davis et al. (2013, 2015)[67,68]	RCT	USA	225/105	45.7
Phillips et al. (2013, 2015)[69,70]	RCT	USA	163/130	45.3/43.7
Rozankovic et al. (2017)[71]	RCT	Croatia	51/50	49
Qizhi et al. (2016) [72]	RCT	China	14/16	64.2
Zhang et al. (2014)[73]	RCT	USA	55/56	44.8
Hisey et al. (2014, 2015)[74,75]	RCT	USA	164/81	43.5
Skeppholm (2015)[76]	RCT	Sweden	73/80	42.2
Jacksont et al. (2016)[77]	RCT	USA	179/81 (single level), 231/105 (2 level)	-

CDA – Cervical disc arthroplasty; ACDF – Anterior cervical discectomy and fusion; RCT – Randomized controlled trials