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Immune infiltration and tumor microenvironment of three TLS subtypes in TCGA cohort. (A) Heatmap of TLS subtypes associated with immune infiltration and immune funtion. (B) the signature of 23 immune cell among TLS subtypes. (C–F) tumor microenvironment of TLS subtypes. (C) subtype had higher immune, stromal, and ESTIMATE scores compared with the scores of the A and B subtypes; however, tumor purity was lower (Figure 5C–5F).
