Table 1. Demographical factors and determinants of sNfL.
|
Total (n=327)
mean (SD) |
<60 years (n=99)
mean (SD) |
≥60 years (n=228)
mean (SD) |
|
| demographical factors | |||
| age, years | 64.6 (10.7) | 50.1 (4.5) | 70.9 (4.9) |
| sex, female [%] | 192 [58.7] | 54 [54.5] | 138 [60.5] |
| life-style related factors | |||
| waist-hip-ratio | 0.9 (0.1) | 0.9 (0.1) | 0.9 (0.1) |
| BMI | 26.6 (4.7) | 25.8 (4.8) | 26.9 (4.7) |
| alcohol, yes [%] | 196 [59.9] | 64 [64.6] | 132 [57.9] |
| kidney function | |||
| eGFR | 74.2 (14.9) | 84.6 (11.8) | 69.7 (13.8) |
| creatinine [mg/dl] | 0.9 (0.2) | 0.9 (0.2) | 1 (0.2) |
| Urea [mg/dl] | 33.9 (11.1) | 29.6 (7.9) | 35.8 (11.7) |
| uric acid [mg/dl] | 5.5 (1.4) | 5.3 (1.3) | 5.6 (1.4) |
| liver function | |||
| GPT [U/l] | 24.3 (11.8) | 26.6 (13.5) | 23.3 (10.9) |
| GOT [U/l] | 26.1 (7.8) | 25.7 (8.8) | 26.3 (7.3) |
| GGT [U/l] | 31.4 (27.6) | 33.5 (38.6) | 30.5 (21.2) |
| AP [U/l] | 66.3 (17.4) | 63.4 (17.9) | 67.5 (17.1) |
| cerebrovascular risk factors | |||
| hypertension, yes [%] | 228 [69.7] | 47 [47.5] | 181 [79.4] |
| hypercholesterolemia, yes [%] | 54 [16.5] | 2 [2] | 52 [22.8] |
| diabetes, yes [%] | 24 [7.3] | 1 [1] | 23 [10.1] |
| systolic blood pressure [mmHg] | 137.9 (21.5) | 127.1 (18.8) | 142.6 (21) |
| diastolic blood pressure [mmHg] | 86.7 (9.3) | 87 (9.9) | 86.6 (9) |
| Cholesterol [mg/dl] | 209.2 (39.5) | 208.9 (35) | 209.4 (41.3) |
| HDL [mg/dl] | 68.4 (20.1) | 67.6 (21.5) | 68.7 (19.5) |
| LDL [mg/dl] | 119.6 (31.9) | 118.3 (29.4) | 120.2 (33) |
| Triglycerides [mg/dl] | 116.9 (72.4) | 123.6 (94.8) | 114 (60.2) |
| Hba1c [mg/dl] | 5.6 (0.5) | 5.4 (0.3) | 5.7 (0.6) |
| blood volume | 4.5 (0.8) | 4.7 (0.9) | 4.4 (0.7) |
Mean and standard deviation (SD) are shown if not otherwise stated.