Table 2. μCT analysis of trabecular and cortical bone in 4- and 13-month-old Dmp1-PPRKO and control. Trabecular bone parameters measured in L5 vertebrae and distal femurs. Cortical bone parameters measured in midshaft of femurs. Values are presented as mean ± SEM, two-tailed t test assuming equal variance was performed to compare control vs. Dmp1-PPRKO male mice at 4- and 13-months of age. p < 0.05 in bold and italics.
| Parameter | 4-month-old | 13-month-old | ||||
| Control | Dmp1-PPRKO | p value | Control | Dmp1-PPRKO | p value | |
| L5 vertebrae | n = 6 | n = 10 | n = 7 | n = 11 | ||
| BV/TV (%) | 27.4 ± 1.3 | 33.0 ± 0.5 | <0.001 | 24.1 ± 1.5 | 19.4 ± 0.9 | 0.011 |
| Tb.N (/mm) | 5.24 ± 0.149 | 5.52 ± 0.087 | 0.101 | 4.59 ± 0.23 | 4.01 ± 0.16 | 0.052 |
| Tb.Th (mm) | 0.052 ± 0.001 | 0.060 ± 0.001 | <0.001 | 0.052 ± 0.002 | 0.049 ± 0.002 | 0.137 |
| Tb.Sp (mm) | 0.14 ± 0.007 | 0.12 ± 0.003 | 0.015 | 0.17 ± 0.014 | 0.21 ± 0.010 | 0.053 |
| Distal femurs | n = 7 | n = 10 | n = 12 | n = 15 | ||
| BV/TV (%) | 18.0 ± 1.4 | 23.6 ± 1.0 | 0.003 | 10.4 ± 1.1 | 6.8 ± 0.7 | 0.013 |
| Tb.N (/mm) | 4.38 ± 0.2 | 4.87 ± 0.1 | 0.056 | 2.46 ± 0.2 | 1.69 ± 0.2 | 0.002 |
| Tb.Th (mm) | 0.041 ± 0.001 | 0.048 ± 0.001 | <0.001 | 0.051 ± 0.003 | 0.047 ± 0.003 | 0.285 |
| Tb.Sp (mm) | 0.19 ± 0.01 | 0.16 ± 0.01 | 0.028 | 0.39 ± 0.03 | 0.62 ± 0.06 | 0.002 |
| Midshaft femurs | n = 7 | n = 10 | n = 12 | n = 16 | ||
| Cort.Th (mm) | 0.181 ± 0.004 | 0.197 ± 0.003 | 0.005 | 0.193 ± 0.005 | 0.187 ± 0.003 | 0.30 |
| Cort.Dens (mmHA/ccm) | 1239.8 ± 3.9 | 1218.6 ± 4.4 | 0.004 | 1288.5 ± 9.5 | 1279.4 ± 7.1 | 0.44 |
| Cort.A (mm2) | 0.69 ± 0.02 | 0.81 ± 0.02 | <0.001 | 0.87 ± 0.02 | 0.89 ± 0.02 | 0.50 |
| MA (mm2) | 0.77 ± 0.03 | 0.89 ± 0.04 | 0.040 | 0.98 ± 0.10 | 0.78 ± 0.14 | 0.27 |
| Cort. Por (%) | 0.26 ± 0.03 | 0.23 ± 0.02 | 0.48 | 0.56 ± 0.12 | 0.73 ± 0.14 | 0.37 |
| pMOI (mm4) | 0.26 ± 0.01 | 0.35 ± 0.02 | 0.002 | 0.44 ± 0.02 | 0.49 ± 0.04 | 0.28 |