Table 1. Non-redundant SMs for reprogramming cocktails and their main bioactivities.
| SM | Main bioactivity | Cocktail | |||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | ||
| CHIR99021 | GSK3 inhibitor | ||||||||||
| RepSox | TGFβ inhibitor [can replace Sox2] |
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| VPA | HDAC inhibitor | ||||||||||
| Forskolin | cAMP activator [can replace Oct4] |
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| Parnate | Inhibitor of LSD1 acting on histone H3 | ||||||||||
| DZNep | Inhibitor of HMT EZH and SAH synthesis |
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| AM 580 | Nuclear RARα selective agonist |
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| EPZ004777 | DOT1L histone (H3K79) methyltransferase inhibitor |
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| NaB | HDAC inhibitor | ||||||||||
| TTNPB | Synthetic retinoic acid receptor ligand |
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| BrdU | Synthetic analog of thymidine [can replace Oct4] | ||||||||||
| LiCl | GSK3 inhibitor | ||||||||||
| SB431542 | TGFβ inhibitor [can replace RepSox] |
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| Tranilast | TGFβ inhibitor [can replace RepSox] |
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| Trichostatin A | HDAC inhibitor | ||||||||||
| Li2CO3 | GSK3 inhibitor | ||||||||||
| 5'-aza-dC | DNMT inhibitor | ||||||||||
| SGC0946 | DOT1L histone (H3K79) methyltransferase inhibitor | ||||||||||
| Cyclic pifithrin-a | p53 inhibitor | ||||||||||
| A-83-01 | TGF-beta receptor inhibitor |
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| Thiazovivin | Rho Kinase (ROCK) inhibitor | ||||||||||
| PD0325901 | Potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor | ||||||||||