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. 2021 Dec 17;13(24):25739–25762. doi: 10.18632/aging.203791

Table 3. SMs as human metabolites.

Name Role in induced cell reprogramming
(inducer/enhancer)
Chemical class
5'-Azacytidine (5'-azaC) Enhancer Nucleotides and nucleotide derivatives
5'-Aza-2'-deoxycytidine Enhancer Nucleotides and nucleotide derivatives
7-hydroxyflavone Enhancer Flavonoids
90-D3 (Vitamin D3) Enhancer Steroids and steroid derivatives
Apigenin Enhancer Flavonoids
Caffeic acid Putative enhancer or inducer Cinnamic acids and derivatives
Chlorogenic acid Putative enhancer or inducer Fatty acids and derivatives
Curcumin Enhancer Diarylheptanoids
Dasatinib Inducer Benzene and derivatives
Dexamethasone Enhancer Steroids and steroid derivatives
EGCG Enhancer Flavonoids
Fisetin Enhancer Flavonoids
Forskolin Inducer Benzofurans
Fru-2,6-P2 Enhancer Organooxygen compounds
Luteolin Enhancer Flavonoids
N-acetyl-cysteine Enhancer Amino acids and derivatives
Sodium Butyrate (NaB) Inducer and enhancer Fatty acids and derivatives
Prostaglandin E2 Enhancer Fatty acids and derivatives
Quercetin Enhancer Flavonoids
Rapamycin Enhancer Macrolide lactams
Resveratrol Enhancer Stilbenes
Retinoic acid Enhancer Prenol lipids
SAHA Enhancer Benzene and derivatives
Spermidine Enhancer Organonitrogen compounds
Valproic acid Inducer Fatty acids and derivatives
Vitamin A (Retinol acetate) Enhancer Prenol lipids
Vitamin C (Ascorbic acid; Ascorbate) Enhancer Dihydrofurans
Zolpidem Enhancer Azoles