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. 2022 Jan 11;29(5):774–784.e8. doi: 10.1016/j.chembiol.2021.11.006

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Pharmacokinetic study of ACF in CD-1 mice

(A–D) The mice were given a single dose intravenously (IV; A and C) (15 mg/kg) and orally (PO; B and D) (100 mg/kg) of the commercially available drug composed of ACF, proflavine (PF), side-methylated ACF, and side-methylated PF. Plasma concentrations (A and B) and lung concentrations (C and D) are shown. Purple dashed lines indicate the ACF concentration (112 ng/mL) needed to inhibit the viral replication in HAE cultures. PF and side-methylated PF have much higher bioavailability, and lung exposure to these components is very high. Each of the time point treatment group included 4 animals. Error bars have been calculated as standard deviation of values measured at respective time point.