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. 2022 Jan 11;29(5):774–784.e8. doi: 10.1016/j.chembiol.2021.11.006

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© 2021 The Authors

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Inhibition of virus replication by ACF in vivo

Each group consisted of 10 animals, except for the reference group, where 15 animals were included. Oral and intramuscular delivery were tested. Remdesivir was used as positive control. Virus replication in different organs was assessed using RT-qPCR. A strong reduction of virus level is visible in the brain of treated groups. ACF caused a marked reduction of virus load in the lungs when administered orally. Data are presented as geometric mean with 95% confidence intervals.