Table 4.
Events Within 30 Days of a Positive SARS‐CoV‐2 Test Result, by Statin Use, n (%)
| Cohort | Number in each age stratum with outcomes | Crude OR (95% CI) | OR adjusted for age and sex only (95% CI) | Fully adjusted OR (95% CI) | aOR from logistic regression with IPTW (95% CI) | ||
|---|---|---|---|---|---|---|---|
| All | Non‐statin user | Statin user | |||||
| Age between 18 and 65 y | 5342 | 4989 | 353 | ||||
| All‐cause hospitalization | 183 (3.43) | 147 (2.95) | 36 (10.20) | 3.74 (2.55–5.48) | 2.05 (1.37–3.09) | 1.25 (0.73–2.14) | 0.81 (0.42–1.58) |
| At least 1 ED visit | 618 (11.57) | 554 (11.10) | 64 (18.13) | 1.77 (1.33–2.36) | 1.38 (1.02–1.86) | 0.82 (0.56–1.19) | 0.45 (0.27–0.75) |
| ICU admission | 39 (0.73) | 27 (0.54) | 12 (3.40) | 6.47 (3.25–12.88) | 3.18 (1.51–6.70) | 2.93 (1.28–6.69) | 2.30 (0.87–6.08) |
| Death | 8 (0.15) | 6 (0.12) | 2 (0.57) | 4.73 (0.95–23.53) | 2.03 (0.37–11.02) | 0.46 (0.09–2.41) | 0.29 (0.00–58.33) |
| Death or ICU admission | 43 (0.8) | 30 (0.60) | 13 (3.68) | 6.32 (3.27–12.23) | 3.08 (1.51–6.28) | 2.94 (1.15–7.48) | 2.13 (0.82–5.55) |
| Any event (any outcome above within 30 d) | 648 (12.13) | 582 (11.67) | 66 (18.70) | 1.74 (1.31–2.31) | 1.34 (1.00–1.81) | 0.81 (0.56–1.18) | 0.45 (0.28–0.74) |
| Age between 66–75 y | 2383 | 1293 | 1090 | ||||
| All‐cause hospitalization | 766 (32.14) | 397 (30.70) | 369 (33.85) | 1.13 (0.95–1.35) | 1.09 (0.92–1.3) | 0.84 (0.66–1.06) | 0.91 (0.73–1.12) |
| At least one ED visit | 820 (34.41) | 440 (34.03) | 380 (34.86) | 1.07 (0.80–1.43) | 1.05 (0.78–1.41) | 0.90 (0.72–1.12) | 1.01 (0.82–1.25) |
| ICU admission | 232 (9.74) | 115 (8.89) | 117 (10.73) | 0.86 (0.29–2.56) | 0.82 (0.28–2.39) | 0.57 (0.21–1.59) | 0.51 (0.12–2.23) |
| Death | 290 (12.17) | 131 (10.13) | 159 (14.59) | 1.50 (1.17–1.92) | 1.45 (1.12–1.86) | 1.19 (0.86–1.64) | 1.07 (0.78–1.48) |
| Death or ICU admission | 436 (18.3) | 213 (16.47) | 223 (20.46) | 1.17 (0.73–1.85) | 1.15 (0.76–1.73) | 0.94 (0.72–1.23) | 0.90 (0.69–1.17) |
| Any event (any outcome above within 30 d) | 1170 (49.1) | 618 (47.80) | 552 (50.64) | 1.10 (0.93–1.30) | 1.06 (0.90–1.25) | 0.90 (0.73–1.11) | 0.93 (0.76–1.14) |
| Age >75 y | 6307 | 3772 | 2535 | ||||
| All‐cause hospitalization | 1657 (26.27) | 827 (21.92) | 830 (32.74) | 1.8 (1.43–2.26) | 1.50 (1.33–1.70) | 1.41 (0.83–2.38) | 1.19 (1.05–1.36) |
| At least one ED visit | 1388 (22.01) | 674 (17.87) | 714 (28.17) | 1.82 (1.62–2.06) | 1.54 (1.37–1.75) | 1.41 (1.10–1.82) | 1.41 (1.23–1.61) |
| ICU admission | 200 (3.17) | 95 (2.52) | 105 (4.14) | 2.68 (0.64–11.22) | 1.92 (0.46–8.03) | 2.08 (0.35–12.29) | 1.61 (0.42–6.21) |
| Death | 1865 (29.57) | 1182 (31.34) | 683 (26.94) | 0.81 (0.72–0.91) | 0.85 (0.76–0.95) | 0.81 (0.69–0.96) | 0.76 (0.67–0.86) |
| Death or ICU admission | 1954 (30.98) | 1229 (32.58) | 725 (28.60) | 0.83 (0.75–0.92) | 0.86 (0.76–0.96) | 0.82 (0.72–0.93) | 0.76 (0.67–0.86) |
| Any event (any outcome above within 30 d) | 3127 (49.58) | 1786 (47.35) | 1341 (52.90) | 1.38 (0.98–1.96) | 1.38 (0.86–2.20) | 1.08 (0.76–1.53) | 0.97 (0.87–1.09) |
aOR indicates adjusted odds ratio; ED, emergency department; ICU, intensive care unit; IPTW indicates inverse probability of treatment weighting analysis using propensity scores; and OR, odds ratio.