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. 2021 Oct 29;10(21):e022095. doi: 10.1161/JAHA.121.022095

Figure 2. Changes in cytokines and their correlation with heart rate‐corrected PR‐interval (PRc‐interval) in patients with inflammatory diseases, during active disease (PRE) and after therapeutic interventions resulting in CRP decrease >75% when compared with the baseline (POST), and controls (C).

Figure 2

A, Comparison of interleukin‐6 (IL‐6) levels in patients with inflammatory diseases, in PRE and POST conditions, and controls; two‐tail Dunnett’s test, ***P<0.001, n.s. not significant. B, Relationship between PRc‐interval and IL‐6 levels; Spearman test; C, Comparison of interleukin‐1 (IL‐1) levels in patients with inflammatory diseases, in PRE and POST conditions, and controls; two‐tail Wilcoxon matched‐pairs test, *P<0.05; two‐tail Dunnett’s test, n.s. not significant. D, Relationship between PRc‐interval and IL‐1 levels; Spearman test. Patients, n=46; controls, n=30. Horizontal dotted line indicates the upper limit values in a reference healthy population, ie, 1.25 pg/mL for IL‐6, and 0.29 pg/mL for IL‐1.