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. 2021 Oct 29;10(21):e022095. doi: 10.1161/JAHA.121.022095

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© 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Systemic inflammatory activation, by increasing circulating IL‐6 levels could promote PR‐interval prolongation by affecting the electric properties of different cells in the atrioventricular (AV) node. The results of the present study suggest that these changes may consist, at least in part, in a down‐regulation of the gap‐junctions containing connexin43 (Cx43), which couple adjacent myocytes, as well as myocytes and macrophages, at the AV node.