Table 3.

Univariable Cox Regression Analysis for Rehospitalization With Major Bleeding in 66 295 Patients With Myocardial Infarction Treated With PCI and Subsequent Dual Antiplatelet Therapy

	HR (95% CI)	P value
Age (for each 10 y increase)*	1.5 (1.4–1.5)	<0.001
Age ≥75 y	2.0 (1.8–2.2)	<0.001
Body weight <60 kg	1.8 (1.5–2.1)	<0.001
Women	1.1 (1.0–1.2)	0.239
ST‐segment–elevation myocardial infarction	1.1 (1.0–1.2)	0.048
Hypertension	1.3 (1.2–1.4)	<0.001
Hyperlipidemia	1.0 (0.9–1.1)	0.619
Current smoking	1.0 (0.9–1.2)	0.545
Diabetes	1.2 (1.1–1.4)	0.002
Peripheral artery disease	2.1 (1.7–2.6)	<0.001
Heart failure	2.0 (1.6–2.5)	<0.001
Chronic obstructive pulmonary disease	1.7 (1.4–2.1)	<0.001
Cancer within 3 y	2.6 (2.1–3.3)	<0.001
Dementia	2.5 (1.4–4.7)	0.003
Previous myocardial infarction	1.1 (0.9–1.2)	0.385
Previous PCI	1.0 (0.8–1.2)	0.943
Previous coronary artery bypass graft	1.0 (0.8–1.3)	0.935
Previous stroke	1.5 (1.2–1.8)	<0.001
Previous bleeding	2.6 (2.2–3.1)	<0.001
Hemoglobin (for each 10 g/L increase) †	0.5 (0.4–0.5)	<0.001
Anemia ‡	2.4 (2.1–2.7)	<0.001
Creatinine clearance (for each 10 mL/min per 1.73 m2 increase) §	0.9 (0.8–0.9)	<0.001
Kidney dysfunction ‖	1.7 (1.5–1.9)	<0.001
Drug‐eluting stent	1.3 (1.1–1.5)	<0.001
Radial access	1.0 (0.9–1.1)	0.970
Discharge medications
Ticagrelor ¶	1.4 (1.2–1.5)	<0.001
Prasugrel ¶	1.1 (0.7–1.6)	0.722
Angiotensin‐converting enzyme inhibitor/angiotensin II receptor blocker	0.9 (0.8–1.0)	0.146
β‐blockers	0.8 (0.7–1.0)	0.053
Statins	0.8 (0.6–1.0)	0.064

HR indicates hazard ratio; and PCI, percutaneous coronary intervention.

^*Age was truncated below 50 years.

^† Hemoglobin was truncated above 120 g/L and below 100 g/L.

^‡ Anemia is hemoglobin <120 g/L for women and <130 g/L for men.

^§ Creatinine clearance was truncated above 100 mL/min per 1.73 m².

^‖ Kidney dysfunction is creatinine clearance <60 mL/min per 1.73 m².

^¶ Clopidogrel was used as reference.