Table 4.
Multivariable Cox Regression Analysis for Rehospitalization With Major Bleeding in 51 713 Patients With Myocardial Infarction Treated With PCI and Subsequent Dual Antiplatelet Therapy
| HR (95% CI) | P value | |
|---|---|---|
| Age (for each 10 y increase)* | 1.3 (1.2–1.4) | <0.001 |
| Body weight <60 kg | 1.3 (1.1–1.6) | 0.013 |
| ST‐segment–elevation myocardial infarction | 1.1 (1.0–1.2) | 0.140 |
| Hypertension | 0.9 (0.8–1.1) | 0.237 |
| Diabetes | 1.0 (0.9–1.2) | 0.744 |
| Peripheral artery disease | 1.4 (1.1–1.8) | 0.019 |
| Heart failure | 1.3 (1.0–1.7) | 0.024 |
| Chronic obstructive pulmonary disease | 1.3 (1.1–1.7) | 0.010 |
| Cancer within 3 y | 1.6 (1.2–2.1) | 0.004 |
| Dementia | 2.1 (1.1–4.1) | 0.028 |
| Previous stroke | 0.8 (0.6–1.1) | 0.175 |
| Previous bleeding | 2.1 (1.7–2.6) | <0.001 |
| Hemoglobin (for each 10 g/L increase) † | 0.6 (0.5–0.7) | <0.001 |
| Creatinine clearance (for each 10 mL/min per 1.73 m2 increase) ‡ | 1.0 (0.9–1.0) | 0.036 |
| Drug‐eluting stent | 1.1 (1.0–1.3) | 0.099 |
| Discharge medications | ||
| Ticagrelor § | 1.4 (1.2–1.6) | <0.001 |
| Angiotensin‐converting enzyme inhibitor/angiotensin II receptor blocker | 0.9 (0.8–1.1) | 0.429 |
| β‐blockers | 0.9 (0.7–1.0) | 0.094 |
| Statins | 1.2 (0.8–1.6) | 0.373 |
HR indicates hazard ratio; and PCI, percutaneous coronary intervention.
*
Age was truncated below 50 years.
†
Hemoglobin was truncated above 120 g/L and below 100 g/L.
‡
Creatinine clearance was truncated above 100 mL/min per 1.73 m2.
§
Clopidogrel was used as reference.