Table 5.
Univariable Cox Regression Analysis for Stent Thrombosis Within 12 Months After Discontinuation of Dual Antiplatelet Therapy in 60 227 Patients With Myocardial Infarction Treated With PCI Who Did Not Continue With Dual Antiplatelet Therapy Beyond 12 Months From Their Index Myocardial Infarction
HR (95% CI) | P value | |
---|---|---|
Age (for each 10 y increase)* | 0.9 (0.8–1.1) | 0.274 |
Age ≥75 y | 0.8 (0.5–1.3) | 0.315 |
Body weight <60 kg | 0.5 (0.2–1.7) | 0.298 |
Women | 0.7 (0.4–1.1) | 0.111 |
ST‐segment–elevation myocardial infarction | 1.1 (0.7–1.6) | 0.722 |
Hypertension | 0.9 (0.6–1.3) | 0.485 |
Hyperlipidemia | 2.0 (1.4–3.0) | <0.001 |
Current smoking | 1.1 (0.7–1.8) | 0.574 |
Diabetes | 1.1 (0.6–1.8) | 0.754 |
Diabetes with insulin therapy | 1.2 (0.6–2.5) | 0.634 |
Peripheral artery disease | 2.6 (1.2–5.7) | 0.013 |
Heart failure | 1.3 (0.5–3.5) | 0.638 |
Chronic obstructive pulmonary disease | 0.6 (0.2–1.8) | 0.577 |
Cancer within 3 y | 0.5 (0.1–3.5) | 0.471 |
Previous myocardial infarction | 2.1 (1.4–3.4) | 0.001 |
Previous PCI | 2.9 (1.8–4.6) | <0.001 |
Previous coronary artery bypass graft | 3.5 (2.0–6.2) | <0.001 |
Previous stroke | 1.6 (0.7–3.5) | 0.228 |
Previous bleeding | 0.8 (0.3–2.6) | 0.723 |
Hemoglobin (for each 10 g/L increase) † | 0.9 (0.5–1.5) | 0.578 |
Anemia ‡ | 1.2 (0.7–2.0) | 0.544 |
Creatinine clearance (for each 10 mL/min per 1.73 m2 increase) § | 1.0 (0.9–1.1) | 0.986 |
Kidney dysfunction ‖ | 1.5 (0.9–2.4) | 0.101 |
Bifurcation lesion | 0.8 (0.4–1.5) | 0.455 |
Complex lesion | 2.0 (1.3–3.1) | 0.001 |
Drug–eluting stent | 0.4 (0.3–0.6) | <0.001 |
Stent length (for each mm increase) | 1.0 (1.0–1.0) | 0.297 |
HR indicates hazard ratio; and PCI, percutaneous coronary intervention.
Age was truncated below 50 years.
Hemoglobin was truncated above 120 g/L and below 100 g/L.
Anemia is hemoglobin <120 g/L for women and <130 g/L for men.
Creatinine clearance was truncated above 100 mL/min per 1.73 m2.
Kidney dysfunction is creatinine clearance <60 mL/min per 1.73 m2.