Table 3.
Cox Regression Model for Prognostic Prediction of Adverse Outcomes With RHC‐PAC
| Unadjusted HR (95% CI) | P value |
Adjusted HR (95% CI) |
P value |
Adjusted HR (95% CI) |
P value | |
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | |||||
| Primary End Point | ||||||
| Age, 5‐y increments | 1.14 (0.95–1.42) | 0.164 | 1.12 (0.91–1.42) | 0.312 | ||
| Female | 1.05 (0.55–2.01) | 0.882 | 0.86 (0.44–1.70) | 0.666 | ||
| eGFR, 5‐mL/min per 1.73 m2 increments | 0.93 (0.86–1.01) | 0.098 | ||||
| NT‐proBNP, 1000‐ng/L increments | 1.05 (1.00–1.08) | 0.040 | 1.06 (1.01–1.10) | 0.023 | ||
| PAWP, 1‐mm Hg increments | 1.04 (0.99–1.08) | 0.079 | 1.02 (0.95–1.09) | 0.588 | ||
| RAP, 1‐mm Hg increments | 1.05 (0.97–1.12) | 0.238 | 0.99 (0.89–1.11) | 0.900 | ||
| PVR, 1‐dyne/sec/cm5 increments | 1.01 (0.97–1.03) | 0.736 | 0.99 (0.96–1.02) | 0.657 | ||
| RHC‐PAC, 1‐mL/mm Hg increments | 0.70 (0.52–0.91) | 0.005 | 0.71 (0.50–0.96) | 0.023 | 0.73 (0.53–0.96) | 0.021 |
| All‐cause mortality | ||||||
| RHC‐PAC, 1‐mL/mm Hg increments | 0.60 (0.34–0.93) | 0.019 | ||||
| HF rehospitalization | ||||||
| RHC‐PAC, 1‐mL/mm Hg increments | 0.73 (0.52–0.97) | 0.029 | ||||
Cox proportional hazard models of RHC‐PAC for composite end point, all‐cause mortality, and heart failure rehospitalization. The composite end point was defined as all‐cause mortality or heart failure rehospitalization. Multivariable Cox regression for primary end point was performed using covariates as follows: model 1—hemodynamic parameters of PAWP, RAP, and PVR; model 2—clinical aspects of age, sex, and NT‐proBNP, respectively. eGFR indicates estimated glomerular filtration rate; HF, heart failure; HR, hazard ratio; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; PAWP, pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; RAP, right atrial pressure; and RHC‐PAC, pulmonary artery capacitance calculated with right heart catheterization.