Table 1.
Clinical Characteristics of Patients With Hypertrophic Cardiomyopathy
| Variables | Total (n=150) | Group 1 (CFVR >2) (n=87) | Group 2 (CFVR ≤2) (n=63) |
P value Group 1 vs. Group 2 |
|---|---|---|---|---|
| Age, y | 48±15 | 47±15 | 50±16 | 0.180 |
| Female sex, no. (%) | 82 (54.7) | 40 (46) | 42 (66.7) | 0.012 |
| BSA, m2 | 1.84±0.18 | 1.87±0.16 | 1.81±0.20 | 0.059 |
| Angina, no. (%) | 83 (55.3) | 43 (49.4) | 40 (63.5) | 0.087 |
| Hypertension, no. (%) | 51 (34) | 26 (29.9) | 25 (39.7) | 0.211 |
| Syncope, no. (%) | 21 (14) | 8 (12.7) | 13 (14.9) | 0.696 |
| Family history of HCM, no. (%) | 53 (35.3) | 31 (35.6) | 22 (34.9) | 0.928 |
| Family history of SCD, no. (%) | 17 (11.3) | 8 (9.2) | 9 (14.3) | 0.332 |
| HCM Risk SCD score | 3.13±2.10 | 2.97±2.09 | 3.35±2.10 | 0.266 |
| NYHA functional class, no. (%) | 0.003 | |||
| I | 92 (61.3) | 62 (71.3) | 30 (47.6) | |
| II | 58 (38.7) | 25 (28.7) | 33 (52.4) | |
| Unsustained ventricular tachycardia on Holter ECG, no. (%) | 28 (18.7) | 15 (17.2) | 13 (20.6) | 0.599 |
| Paroxysmal atrial fibrillation, no. (%) | 28 (18.7) | 14 (16.1) | 14 (22.2) | 0.342 |
| Medical therapy, no. (%) | ||||
| Beta blockers | 126 (84) | 72 (82.8) | 54 (85.7) | 0.626 |
| Ca antagonists | 25 (16.7) | 11 (12.6) | 14 (22.2) | 0.120 |
| ACEI/ARB | 38 (25.3) | 22 (25.3) | 16 (25.4) | 0.988 |
| Diuretic | 27 (18) | 8 (9.2) | 19 (30.2) | 0.001 |
| Amiodarone | 19 (12.7) | 10 (11.5) | 9 (14.3) | 0.612 |
| Anticoagulants | 28 (18.7) | 14 (16.1) | 14 (22.2) | 0.342 |
| Baseline heart rate, beats/min | 70±14 | 67±12 | 73±16 | 0.008 |
| Peak heart rate during hyperemia, beats/min | 76±16 | 74±15 | 78±18 | 0.135 |
| Diastolic blood pressure, mm Hg | 77±9 | 76±9 | 78±9 | 0.225 |
| Systolic blood pressure, mm Hg | 120±15 | 118±14 | 121±16 | 0.213 |
ACEI indicates angiotensin‐converting enzyme inhibitors; ARB, angiotensin II receptor blockers; BSA, body surface area; CFVR, coronary flow velocity reserve; HCM, hypertrophic cardiomyopathy; NYHA, New York Heart Association; Plus–minus values are means ±SD; and SCD, sudden cardiac death.