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. 2021 Oct 6;10(20):e022568. doi: 10.1161/JAHA.121.022568

Figure 2. Hemodynamic parameters in Angiotensin II/L‐Nω‐nitroarginine methyl ester‒treated hemizygous Rock mice.

Figure 2

Twelve‐week‐old, male wild‐type littermates, Rock1 +/−, and Rock2 +/− mice were treated with angiotensin II (Ang II; 500 ng/kg per minute) and L‐Nω‐nitroarginine methyl ester (L‐NAME, 0.5 g/L, drinking water) for 4 weeks. A, Pulse pressure, (B) ΔP, augmentation point to peak systolic pressure, and (C) augmentation index were obtained by pressure waveforms from pressure transducers in the aorta. D, Systolic internal diameter, (E) diastolic internal diameter, (F) change in the systolic and diastolic internal diameters of the aortic root, and (G) aortic wall thickness were determined by ultrasonography. H, Pulse wave velocity was determined by pressure waveforms in aortic root and abdominal aorta at the level of renal artery. Saline group: wild‐type (n=4), Rock1 +/− (n=3), and Rock2 +/− (n=3); Ang II/L‐Nω‐nitroarginine methyl ester group: wild‐type (n=5), Rock1 +/− (n=3), and Rock2 +/− (n=4). Results are expressed as mean±SEM. P values were calculated using 1‐way ANOVA with Tukey Honest Significant Difference test. Ang II indicates angiotensin II; PP, pulse pressure; ΔP, augmentation point to peak systolic pressure; Rock, Rho/Rho‐associated coiled‐coil containing kinase; and WT, wild‐type.