Table 2.
Histologic Findings
|
All patients n=37 |
AL n=19 (51%) |
ATTR n=18 (49%) |
P Value | |
|---|---|---|---|---|
| Extent of amyloid deposits (%) | 15 (10–30) | 20 (10–30) | 15 (9–43) | 0.869 |
| Amyloid pattern, n (%) | ||||
| Minimal | 3 (8) | 1 (5) | 2 (11) | 0.719 |
| Focal | 1 (3) | 1 (5) | 0 (0) | |
| Multifocal | 29 (78) | 15 (79) | 14 (78) | |
| Diffuse | 4 (11) | 2 (11) | 2 (11) | |
| Amyloid location, n (%) | ||||
| Interstitial | 11 (30) | 6 (32) | 5 (28) | 0.177 |
| Interstitial and perivascular | 23 (62) | 10 (53) | 13 (72) | |
| Interstitial, perivascular, vascular | 3 (8) | 3 (16) | 0 (0) | |
| Histology score | 9 (8–10) | 9 (8–11) | 8 (7–9) | 0.030 |
| Extent of fibrosis (%) | 15 (10–23) | 10 (10–20) | 19 (12–26) | 0.163 |
| Extent of amyloidosis and fibrosis (%) | 40 (30–49) | 40 (21–45) | 42 (32–51) | 0.313 |
| CD3+, cells/mm3 | 6 (5–10) | 8 (5–10) | 5 (2–6) | 0.035 |
| CD68+, cells/mm3 | 11 (7–16) | 12 (7–18) | 10 (5–18) | 0.147 |
AL indicates amyloid light chain amyloidosis; and ATTR, amyloid transthyretin amyloidosis.