Table 4.

C Statistic for Outcomes With Risk Factors Alone and With Addition of CAC Score Among Adults Aged 30 to 49 Years

	Risk factors	CAC+risk factors	P value*
All‐cause mortality	0.57 (0.52–0.63)	0.59 (0.54–0.64)	0.028
MACE	0.60 (0.57–0.63)	0.63 (0.60–0.66)	<0.001
MI	0.61 (0.57–0.65)	0.70 (0.66–0.74)	<0.001
Stroke	0.58 (0.54–0.62)	0.59 (0.54–0.63)	0.32

Harrell C statistic was used to assess the area under the curve for the primary outcomes accounting for censoring of events. Values are C statistic (95% CI). MACE indicates major adverse cardiovascular events (myocardial infarction [MI], stroke, and cardiac death).

^*Reported P values are derived from the likelihood ratio test comparing the predictive ability of the models with and without coronary artery calcium (CAC) as measured by the −2 log L fit statistics. CAC score was input into the model using ln(CAC+1) transformation. Risk factors consist of the presence of hypertension, hyperlipidemia, diabetes, tobacco use, and ln(age).