Table 2.
Logistic Regression Models for Intracardiac Thrombus Detection (n=5648)
| Univariate | Multivariable (model 1)* | Multivariable (model 2) † | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| TEE | 19.04 (11.50–31.51) | <0.01 | 17.03 (10.17–28.53) | <0.01 | 16.09 (9.65–26.87) | <0.01 |
| TTE | 6.40 (2.33–17.56) | <0.01 | 4.16 (1.49–11.61) | <0.01 | 4.15 (1.49–11.56) | <0.01 |
| Age (per 10‐y increase) | 0.97 (0.78–1.21) | 0.80 | 1.05 (0.81–1.35) | 0.72 | … | … |
| Women | 0.99 (0.63–1.56) | 0.96 | 1.22 (0.74–2.00) | 0.44 | … | … |
| NVAF known before index event | 1.95 (1.18–3.24) | 0.01 | … | … | 1.54 (0.86–2.78) | 0.15 |
| Congestive heart failure | 3.90 (2.29–6.62) | <0.01 | 2.97 (1.66–5.31) | <0.01 | 2.85 (1.60–5.07) | <0.01 |
| Hypertension | 0.94 (0.57–1.57) | 0.82 | 0.82 (0.47–1.40) | 0.46 | … | … |
| Diabetes mellitus | 0.99 (0.59–1.67) | 0.99 | 0.92 (0.53–1.59) | 0.77 | … | … |
| Stroke before index event | 1.29 (0.78–2.13) | 0.32 | 1.21 (0.69–2.13) | 0.50 | … | … |
| Coronary heart disease | 1.11 (0.57–2.17) | 0.75 | 0.99 (0.49–2.01) | 0.98 | … | … |
| Prestroke oral anticoagulants | 2.71 (1.70–4.32) | <0.01 | 2.14 (1.26–3.65) | <0.01 | 1.80 (1.04–3.14) | 0.03 |
| Ischemic stroke as index event | 0.33 (0.14–0.77) | 0.01 | … | … | 0.67 (0.27–1.67) | 0.39 |
NVAF indicates nonvalvular atrial fibrillation; OR, odds ratio; TEE, transesophageal echocardiography; and TTE, transthoracic echocardiography.
Model 1: adjusted for TEE and TTE plus prespecified variables of age, sex, congestive heart failure, hypertension, diabetes mellitus, stroke before index event, coronary heart disease, and prestroke oral anticoagulants. The model showed a c‐statistic of 0.87 and a Hosmer‒Lemeshow Chi‐squared statistic of 7.14 (P=0.52). Number of observations=5641; log likelihood ratio Chi‐squared test statistic=180.10 (P<0.01); and McFadden R 2=0.23.
Model 2: adjusted for TEE and TTE plus those variables showing P<0.05 on univariate models. The model showed a c‐statistic of 0.88 and a Hosmer‒Lemeshow Chi‐squared statistic of 2.28 (P=0.80). Number of observations=5640; log likelihood ratio Chi‐squared test statistic=181.34 (P<0.01); and McFadden R 2=0.23.