Table 3.

Outcomes Between Patients With and Without Intracardiac Thrombus Detection (n=5648)

	Cumulative incidence (total number)	Crude hazard ratio (95% CI)	Adjusted hazard ratio (95% CI)*	Adjusted hazard ratio with shared frailty (95% CI) †
Recurrent ischemic stroke
Intracardiac thrombus (n=79)	10.7% (8)	2.76 (1.29–5.86); P<0.01	2.33 (1.08–5.06); P=0.03	2.35 (1.07–5.16); P=0.03
No thrombus detection (n=5569)	3.3% (182)	1 (reference)	1 (reference)	1 (reference)
Hemorrhagic stroke
Intracardiac thrombus (n=79)	0.0% (0)	…	…	…
No thrombus detection (n=5569)	0.8% (42)	1 (reference)	1 (reference)	1 (reference)
All‐cause death ‡
Intracardiac thrombus (n=79)	6.7% (5)	0.37 (0.15–0.89); P=0.02	0.69 (0.28–1.66); P=0.40	0.73 (0.30–1.78); P=0.49
No thrombus detection (n=5569)	16.2% (900)	1 (reference)	1 (reference)	1 (reference)

CRCS‐K indicates Clinical Research Collaboration for Stroke in Korea; and SAMURAI‐NVAF, Stroke Acute Management with Urgent Risk‐Factor Assessment and Improvement‐Nonvalvular Atrial Fibrillation.

^*Adjusted for registry (CRCS‐K and SAMURAI‐NVAF), age, sex, congestive heart failure, hypertension, diabetes mellitus, history of stroke, coronary heart disease, baseline National Institutes of Health score, warfarin at discharge, and direct oral anticoagulants at discharge.

^† Adjusted for age, sex, congestive heart failure, hypertension, diabetes mellitus, history of stroke, coronary heart disease, baseline National Institutes of Health score, warfarin at discharge, and direct oral anticoagulants at discharge. Shared gamma distributed frailty clustered by participating centers is included into the model.

^‡ Causes of the 905 deaths were stroke (6.1%), cardiovascular events (3.1%), infection (19.6%), and unclear (71.2%).