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. 2021 Nov 2;10(22):e021003. doi: 10.1161/JAHA.121.021003

Figure 5. MicroRNA (miRNA) expression in proximal and bridge epicardial fat and associations with mRNA gene expression.

Figure 5

miRNAs upregulated in proximal vs bridge epicardial fat (epicardial adipose tissue [EAT]) include 3192‐5P, 518D‐3P, and 532‐5P, which correlated inversely with mRNA expression for adipogenesis, angiogenesis, hypoxia/oxidative stress, and thermogenesis in proximal EAT. miRNAs upregulated in bridge EAT included 630, which correlated directly with plaque burden and inversely with adipogenic gene expression in both proximal and bridge EAT. AP2 indicates adipocyte Protein 2; ATGL, adipose tissue triglyceride lipase; CD36, cluster of differentiation 36; FABP4, fatty acid binding protein 4; GLUT4, glucose transporter 4; LAD, left anterior descending coronary artery; LPL, lipoprotein lipase; P22PHOX, NADH oxidase subunit, phox22; PDGF, platelet‐derived growth factor; PGC1‐α, peroxisome proliferator‐activated receptor γ coactivator 1‐α; PPARG, peroxisome proliferator‐activated receptor γ; SOD, superoxide dismutase; and VEGF, vascular endothelial growth factor.