Figure 4. Effects of acalabrutinib on Na⁺ current (I_Na) in right atrial (RA) myocytes.

A, Representative RA I_Na recordings at baseline and after application of 50 µmol/L of acalabrutinib (ACAL (50)). B, RA I_Na I‐V curves at baseline and after application of ACAL (50). C, RA I_Na activation curves at baseline and after application of ACAL (50). D and E, Summary of I_Na voltage for 50% channel activation (V_1/2(act); D) and slope factor (k_(act); E) at baseline and after application of ACAL (50). Data in panels B and C were analyzed by 2‐way repeated measures ANOVA with a Tukey post hoc text; data in panels D and E were analyzed by paired Student t test; n=6 RA myocytes from 3 mice.