Table 4.
Relationship Between Changes in BNP and Changes in Other Parameters
| ΔBNP (pg/mL) | |||||
|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | ||||
| R | P value | β | P value | VIF | |
| ΔBF (bursts/min) (model 1) | 0.50 | 0.034 | 0.57 | 0.018 | 1.05 |
| ΔBF (bursts/min) (model 2) | 0.52 | 0.045 | 1.15 | ||
| ΔBF (bursts/min) (model 3) | 0.62 | 0.037 | 1.54 | ||
| ΔHeart rate, /min | 0.22 | 0.389 | −0.31 | 0.174 | 1.05 |
| ΔSBP, mm Hg | 0.13 | 0.605 | −0.06 | 0.809 | 1.15 |
| ΔDBP, mm Hg | 0.16 | 0.517 | −0.20 | 0.466 | 1.54 |
| ΔBMI, kg/m2 | −0.20 | 0.453 | |||
| ΔHbA1c, % | −0.24 | 0.380 | |||
| Age | 0.07 | 0.787 | |||
| β‐blocker | −0.39 | 0.107 | |||
| ARB or ACE‐I | −0.15 | 0.564 | |||
| Diuretics | −0.13 | 0.612 | |||
Univeriate linear regression analysis was performed between ΔBNP and other parameters. Multivariate linear regression analysis was performed using 3 models below. Model 1: Dependent variable, ΔBNP; independent variables, ΔBF and ΔHR. Model 2: dependent variable, ΔBNP; independent variables, ΔBF and ΔSBP. Model 3: dependent variable, ΔBNP; Independent variables, ΔBF and ΔDBP. ACE‐I indicates angiotensin coverting enzyme inhibitor; ARB, angiotensin Ⅱ receptor blocker; BF, burst frequency; BMI, body mass index; DBP, diastolic blood pressure; HbA1c, hemoglobin A1c; MSNA, muscle sympathetic nerve activity; R, correlation coefficient value in univariate analysis; SBP, systolic blood pressure; VIF, variance inflation factor; and β, standardized coefficients value in multivariate analysis.