Table 1.
DHHC3 substrates identified from MDA-MB-231 cells
| Protein name | Ratio (+ D3/ − D3) | # of peptides | |
|---|---|---|---|
| 1 | SUMF2* | 13.2 | 2 |
| 2 | NOL6 | 3.3 | 2 |
| 3 | LAPTM4A | 3.0 | 3 |
| 4 | CMTM3 | 2.9 | 2 |
| 5 | ITGA6(20526329) | 2.7 | 2 |
| 6 | TMEM192 | 2.6 | 2 |
| 7 | FAM108A1 | 2.5 | 2 |
| 8 | TMEM97(31109310) | 2.5 | 6 |
| 9 | NPC1 (22216111) | 2.4 | 10 |
| 10 | HIST1H1C | 2.4 | 3 |
| 11 | TMEM179B | 2.1 | 2 |
| 12 | OSTC | 2.0 | 2 |
| 13 | TMED1 | 1.9 | 5 |
| 14 | GPX8(28751022) | 1.9 | 6 |
| 15 | M6PR(23984879) | 1.9 | 9 |
| 16 | AGPAT1 | 1.9 | 9 |
| 17 | METTL7B | 1.9 | 2 |
| 18 | SLC4A7 | 1.8 | 6 |
| 19 | BET1 | 1.8 | 2 |
| 20 | DERL2* | 1.8 | 5 |
| 21 | PTRH2 | 1.8 | 18 |
| 22 | CDKAL1 | 1.8 | 4 |
| 23 | SPRY2(20489163) | 1.8 | 2 |
| 24 | AUP1 | 1.8 | 10 |
| 25 | CKAP4 | 1.8 | 79 |
| 26 | SAR1A(31409740) | 1.8 | 2 |
| 27 | PRDX4(24098506) | 1.7 | 3 |
| 28 | SOAT1 | 1.7 | 3 |
| 29 | SCARB1(29976771) | 1.7 | 3 |
| 30 | SPINT2* | 1.7 | 2 |
| 31 | LMF2 | 1.7 | 15 |
| 32 | PCBP2(26907686) | 1.7 | 4 |
| 33 | SCAP*(29902864) | 1.7 | 2 |
| 34 | ZDHHC6 | 1.7 | 2 |
| 35 | ERGIC3(27588471) | 1.7 | 8 |
| 36 | SPRY4 | 1.7 | 24 |
| 37 | TFRC (21447374) | 1.6 | 63 |
| 38 | SRPRB | 1.6 | 2 |
| 39 | MDC1(26870895) | 1.6 | 3 |
| 40 | PTTG1IP | 1.6 | 9 |
| 41 | RCE1 | 1.6 | 3 |
| 42 | CYB5B | 1.6 | 17 |
| 43 | PRDX1(27653015) | 1.6 | 3 |
| 44 | COPA(25030084) | 1.6 | 3 |
| 45 | TSPAN6 | 1.6 | 4 |
| 46 | TIMP2*(15351863) | 1.6 | 2 |
| 47 | TUBB2C | 1.6 | 2 |
| 48 | FAR1(26714049) | 1.5 | 3 |
| 49 | GANAB(25658244) | 1.5 | 2 |
| 50 | TUBA1B | 1.5 | 37 |
| 51 | CD58 | 1.5 | 4 |
| 52 | CLPTM1 | 1.5 | 4 |
| 53 | RPL36 | 1.5 | 2 |
| 54 | MRPS18B | 1.5 | 2 |
| 55 | RHBDL7 | 1.5 | 2 |
| 56 | EBP | 1.5 | 2 |
| 57 | ARL6IP6 | 1.5 | 7 |
| 58 | TM4SF18* | 1.5 | 3 |
| 59 | FADS2(30732887) | 1.5 | 7 |
| 60 | NUP155 | 1.5 | 3 |
| 61 | AP2M1 | 1.5 | 3 |
| 62 | NHP2L1 | 1.5 | 6 |
| 63 | RER1 | 1.5 | 4 |
| 64 | NRSN2 | 1.5 | 2 |
| 65 | GLCE | 1.5 | 2 |
| 66 | TMEM55B | 1.5 | 3 |
| 67 | TOP2A(24995306) | 1.5 | 45 |
| 68 | SLC30A7 | 1.5 | 3 |
| 69 | MGST1(21428695) | 1.5 | 5 |
| 70 | RRP9 | 1.5 | 4 |
| 71 | SHISA3* | 1.5 | 2 |
| 72 | ITM2C | 1.5 | 3 |
| 73 | CD63 | 1.5 | 26 |
| 74 | SCAMP1 | 1.5 | 4 |
| 75 | SERPINH1(24412200) | 1.5 | 6 |
| 76 | CYP51A1(28658622) | 1.5 | 9 |
| 77 | TBL2 | 1.5 | 4 |
| 78 | NOMO2 | 1.5 | 12 |
| 79 | TMEM222 | 1.5 | 2 |
| 80 | RAB7A(27383256) | 1.5 | 17 |
| 81 | MAGT1(31559137) | 1.5 | 6 |
| 82 | NDUFS1(27799543) | 1.5 | 5 |
| 83 | MBOAT7 | 1.5 | 9 |
| 84 | TMX3(31304984) | 1.5 | 3 |
| 85 | PTDSS1 | 1.5 | 5 |
Criteria for inclusion in table: ≥ 2 peptides; + D3/-D3 ratio ≥ 1.5. Proteins that are bolded and italicized, with superscript PMID#s, are functionally linked to oxidative stress, reactive oxygen species and/or endoplasmic reticulum stress
*Proteins that have not been cross-referenced in the swisspalm.org database but contain likely cytoplasmic cysteines as potential sites for palmitoylation