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. 2022 Jan 7;17:91–104. doi: 10.2147/IJN.S344491

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© 2022 Lin et al.

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Scheme 1 — Construction of minocycline (MC)-loaded poly(α-lipoic acid)–methylprednisolone (MP) prodrug nanoparticles (MC-PαLA-MP NPs). (A) Synthesis of PαLA-MP. (B) Self-assembly of MC-PαLA-MP NPs. (C) Intravenous injection of MC-PαLA-MP NPs to treat traumatic spinal cord injury (TSCI) rats. (D) Microenvironment-responsive drug release and the mechanism of phased inflammation inhibition after TSCI.