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. 2022 Jan 7;17:73–89. doi: 10.2147/IJN.S346044

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© 2022 Zhao et al.

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The long-term immunological memory effects of R837@HM-NPs nanovaccine in combination with αPD-1 therapy against the rechallenged 4T1 tumor model. (A) Schematic illustration of R837@HM-NPs nanovaccine in combination with αPD-1 therapy against the rechallenged 4T1 tumor model. (B) Tumor growth curves of the right tumor for different groups of mice (n = 6). (C) Survival curve of mice treated with various formulations after inoculation of the right tumor. Representative flow cytometry data (D) and statistical data (E and F) of T_EM and T_CM in the spleen analyzed by flow cytometry (gated on CD3⁺CD8⁺ T cells) on day 35. (G) Concentration of IFN-γ in serum from tumor-bearing mice isolated on day 35.*P < 0.05, **P < 0.01.