TABLE 1.

Differentially abundant metabolites in S. coelicolor MVs as defined by targeted metabolomics^a

Metabolite	KEGG ID	Functional classes	Concentration (ppm)		F3 MVs vs. F4 MVs fold changeb
			F3 MVs	F4 MVs
Phenylalanine	C00079	Amino acids, amino acid precursors	0.049	0.0138	3.6
Isoleucine	C00407	Amino acids, amino acid precursors	0.0245	0.016	1.5
Leucine	C00123	Amino acids, amino acid precursors	0.0183	0.01025	1.8
Serine	C00065	Amino acids, amino acid precursors	0.0044	0.00285	1.5
Tryptophan	C00078	Amino acids, amino acid precursors	0.01525	0.01085	1.4
Actinorhodin	C06691	Antibiotics	0.1599	0.0772	2.1
Undecylprodigiosin	C12023	Antibiotics	0.00705	0.00515	1.4
Glucose-6-phosphate	C00092	Carbon metabolism components	0.0645	0.05115	1.3
Folate	C00504	Vitamins	0.0095	0.00405	2.3
Vitamin B12	C05776	Vitamins	0.00085	0.00045	1.9

^aCompound name, KEGG ID, functional classification, and abundance profiles of identified metabolites are reported.

^bFold change for each metabolite was calculated by normalizing the amount of F3 fraction to that of its F4 counterpart.