Table 1.
Demographic and clinical characteristics and outcomes of sepsis patients in the CICU compared to other ICUs.
| Non-CICU | CICU | P | |
|---|---|---|---|
| N | 13,637 | 148 | |
| Age (years) | 63 (49–74) | 69 (57–78) | <0.0001 |
| Female sex | 5511 (40.4) | 72 (48.7) | 0.042 |
| Race-ethnicity | <0.0001 | ||
| African | 232 (1.7) | 16 (10.8) | |
| Caucasian | 5963 (43.7) | 84 (56.8) | |
| E-SE Asian | 2325 (17.1) | 13 (8.8) | |
| Hispanic | 2706 (19.8) | 6 (4.1) | |
| W Asian | 726 (5.2) | 3 (2.0) | |
| Other/unknown | 368 (2.7) | 26 (17.6) | |
| SIRS temperature criterion | 10,192 (74.4) | 113 (76.4) | 0.65 |
| SIRS heart rate criterion | 12,266 (90.0) | 133 (89.9) | 0.97 |
| SIRS respiratory rate criterion | 11,919 (87.4) | 138 (93.2) | 0.033 |
| SIRS leukocyte criterion | 11,256 (82.5) | 116 (78.4) | 0.19 |
| Number of SIRS criteria | 4 (3–4) | 4 (3–4) | 0.61 |
| Proven infection | 9253 (67.9) | 94 (63.5) | 0.26 |
| Acute organ dysfunction | |||
| Circulatory dysfunction | 10,158 (74.5) | 103 (69.6) | 0.18 |
| Respiratory dysfunction | 11,099 (81.4) | 118 (79.7) | 0.61 |
| Hematologic dysfunction | 4615 (33.8) | 39 (26.4) | 0.055 |
| Renal dysfunction | 6209 (45.5) | 55 (37.2) | 0.042 |
| Hepatic dysfunction | 2603 (19.1) | 15 (10.1) | 0.006 |
| Metabolic abnormality | 5914 (43.4) | 29 (19.6) | <0.001 |
| CNS dysfunction | 4488 (32.9) | 30 (20.3) | 0.001 |
| Total number of organ dysfunctions | 3 (2–4) | 2 (1–4) | <0.0001 |
| SOFA scorea | 9 (7–12) | 7 (5–9) | <0.0001 |
| Site of infection | <0.001 | ||
| Abdominal-pelvic | 3101 (22.7) | 14 (9.5) | |
| Bone/joint | 194 (1.4) | 1 (0.7) | |
| Hematogenous spread | 823 (6.0) | 13 (8.8) | |
| Indwelling vascular catheter | 201 (1.5) | 1 (0.7) | |
| Lung | 6227 (45.7) | 76 (51.4) | |
| CNS | 208 (1.5) | 0 (0) | |
| Skin | 697 (5.1) | 4 (2.7) | |
| Urinary tract | 1029 (7.6) | 27 (18.2) | |
| Other/unknown | 697 (5.1) | 4 (2.7) | |
| Fungal infection | 1222 (9.0) | 15 (10.1) | 0.62 |
| Gram positive infection | 4492 (32.9) | 44 (29.7) | 0.41 |
| Gram negative infection | 5721 (42.0) | 52 (35.1) | 0.095 |
| Viral infection | 182 (1.3) | 1 (0.7) | 0.49 |
| Comorbidities | |||
| Chronic lung disease | 2291 (16.8) | 39 (26.4) | 0.002 |
| Congestive heart failure | 1909 (14.0) | 41 (27.7) | <0.001 |
| CKD | 1431 (10.5) | 27 (18.2) | 0.002 |
| Chronic liver disease | 851 (6.2) | 10 (6.8) | 0.8 |
| Diabetes | 2916 (21.4) | 33 (22.3) | 0.79 |
| Active cancer | 2005 (14.7) | 13 (8.8) | 0.043 |
| Chronic steroid use | 1258 (9.2) | 12 (8.1) | 0.64 |
| ICU therapies | |||
| Albumin | 2604 (19.1) | 67 (45.3) | <0.001 |
| Fluid resuscitation | 10,733 (78.7) | 116 (78.4) | 0.92 |
| Mechanical ventilation | 11,646 (85.4) | 119 (80.4) | 0.087 |
| Renal replacement therapy | 2846 (20.9) | 39 (26.4) | 0.1 |
| Sedation | 9419 (69.07) | 104 (70.3) | 0.75 |
| Source control procedure | 4944 (36.3) | 25 (16.9) | <0.001 |
| Vasopressors | 10,712 (78.6) | 101 (68.2) | 0.002 |
| ICU length of stay | 10 (5–18) | 10 (4–20) | 0.8 |
| Hospital length of stay | 19 (10–36) | 17 (9–33) | 0.15 |
| Death in ICU | 5211 (38.2) | 57 (38.5) | 0.94 |
| Death in hospital | 5946 (43.6) | 70 (47.3) | 0.37 |
a
(N = 5604 for non-CCU and 84 for CCU).