Figure 10.

Effect of 2-DG on H₂S-ameliorated cognitive dysfunction of ROT-induced PD rats in the MWM test. After pretreatment with NaHS (100 μmol/kg, i.p.) for 1 w, SD rats were injected with ROT (2 mg/kg, s.c.) for 5 w. In the 3^rd week of ROT injection, rats were cotreated with NaHS (100 μmol/kg, i.p.) and 2-DG (3 μg/w, i.c.v.) for 3 w simultaneously. The representative swimming routes of one rat for each group in searching for the platform were recorded on the 1^st and 5^th training days (a). The latency to find the platform in the acquisition phase was recorded (b–e). The number across platform (f) and the percentage of time spent in the target quadrant (g) in the probe trial phase were recorded. The escape latency (h) and average speed (i) of rats in the visible platform phase were recorded. Values are presented as the mean ± S.E.M. (n = 9 − 15). ^∗P < 0.05 vs. control group; ^#P < 0.05 vs. ROT treatment alone group; ^&P < 0.05 vs. ROT and NaHS cotreatment groups.