Figure 6.

Effect of H₂S on the Warburg effect in the hippocampus of ROT-induced PD rats. After pretreatment with NaHS (30 and 100 μmol/kg, i.p.) for 1 w, SD rats were injected with ROT (2 mg/kg, s.c.) for 5 w and NaHS for 3 w simultaneously. The expressions of HKII (a), PKM2 (b), PDK-1 (c), LDHA (d), and PDH (e) in the hippocampus were detected by western blot. The content of lactate (f) in the hippocampus was tested by a lactate assay kit. Values are presented as the mean ± S.E.M. (n = 3). ^∗P < 0.05 and ^∗∗P < 0.01 vs. control group; ^#P < 0.05 and ^##P < 0.01 vs. ROT treatment alone group.