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. 2022 Jan 4;2022:5914541. doi: 10.1155/2022/5914541

Figure 2.

Figure 2

Serum exosomal miR-122 and miR-148a are poorly expressed in HCC and are correlated with prognosis. (a) Volcano plots for the differentially expressed miRs in serum exosome GSE104251 dataset; (b) a heatmap of the top 50 miRs with the highest degree of differential expression in GSE104251 microarray; (c) RT-qPCR was utilized to measure expressions of miR-122, miR-239, miR-148a, miR-447, miR-681, and miR-581 in serum exosomes of 31 healthy subjects and 59 HCC patients; (d) the predictive efficacy of miR-122, miR-239, miR-148a, miR-447, miR-681, and miR-581 for HCC patients was measured using ROC curves; (e) miR-122/148a effects on HCC patient survival rate were predicted using the KM-Plotter website (https://kmplot.com/analysis/); (f–h) the relationships between miR-122/148a expression and the clinical stage, lymph node metastasis, and tumor differentiation level of HCC patients. All experiments were repeated at least three times, and each point represented one subject. Data in panel C were analyzed utilizing the unpaired t-test. ∗p < 0.05;  ∗∗p < 0.01;  ∗∗∗p < 0.001.