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. 2022 Jan 4;2022:9911982. doi: 10.1155/2022/9911982

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Copyright © 2022 Yi Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of miR-539-5p on proliferation, migration, and invasion of ox-LDL stimulated VSMCs. (a) RT-qPCR was used to detect the efficiency of overexpression miR-539-5p in VSMCs. (b) The cell viability of VSMCs after overexpression of miR-539-5p was detected by CCK-8 assay in NC mimic group vs. miR-539-5p mimic group. (c) The expression levels of Ki67 and PCNA protein. (d)–(f) Wound-healing assay (bars = 200 μm) and transwell assay (bars = 200 μm) showed the effects on invasion and migration of VSMCs. The bar graph showed the percentage of cells in each group. (g) The expression of MMP-2 and MMP-9 protein detected by western blot analyses. ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001.