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. 2022 Jan 4;2022:3109165. doi: 10.1155/2022/3109165

Table 6.

Multivariate analysis of overall survival by the clinical pathological stage.

Characteristics		Stage I-II			Stage III-IV
Characteristics		HR	95% CI	P value	HR	95% CI	P value
Age	<65 Y	REF	0.83–3.19	0.156	REF	1.08–3.40	0.027
Age	≥65 Y	1.63	0.83–3.19	0.156	1.91	1.08–3.40	0.027

Sex	Male	REF	0.39–1.15	0.141	REF	0.37–1.03	0.064
Sex	Female	0.66	0.39–1.15	0.141	0.62	0.37–1.03	0.064

Primary site	Rectum	REF	0.68–2.06	0.546	REF	0.64–1.69	0.881
Primary site	Colon	1.19	0.68–2.06	0.546	1.04	0.64–1.69	0.881

Tumor size	<5 cm	REF	0.38–1.33	0.279	REF	0.61–1.69	0.945
Tumor size	5+ cm	0.71	0.38–1.33	0.279	1.02	0.61–1.69	0.945

T stage	T0–T2	REF	0.45–1.76	0.744	REF	0.31–1.77	0.499
T stage	T3–T4	0.89	0.45–1.76	0.744	0.74	0.31–1.77	0.499

N stage	N0	REF	0.45–2.93	0.775	REF	0.73–2.38	0.354
N stage	N1–N3	1.14	0.45–2.93	0.775	1.32	0.73–2.38	0.354

M stage	M0	REF	1.71–184.99	0.016	REF	0.99–2.81	0.052
M stage	M1	17.79	1.71–184.99	0.016	1.68	0.99–2.81	0.052

NLR	Low	REF	1.14–3.75	0.017	REF	0.61–1.77	0.891
NLR	High	2.06	1.14–3.75	0.017	1.04	0.61–1.77	0.891

PLR	Low	REF	0.89–3.14	0.108	REF	0.79–2.25	0.290
PLR	High	1.67	0.89–3.14	0.108	1.33	0.79–2.25	0.290

CEA (ng/mL)	Low	REF	0.69–2.91	0.342	REF	1.13–2.85	0.013
CEA (ng/mL)	High	1.42	0.69–2.91	0.342	1.79	1.13–2.85	0.013