. Author manuscript; available in PMC: 2022 Jan 11.

Published in final edited form as: Pharm Res. 2020 Sep 28;37(10):205. doi: 10.1007/s11095-020-02929-2

Table 2.

Noncompartmental plasma pharmacokinetic parameters for ondansetron following IV dosing of 10 mg/kg in wild-type and Pgp knockout rats

	Male		Female^*
Parameter	Wild-type	Knock-out	Wild-type	Knock-out
t_1/2,plasma (h)	0.52 (0.01)	0.65 (0.04)	0.54	0.64
AUC_{plasma,0−∞} (h·μg·mL⁻¹)	3.83 (0.64)	3.70 (0.49)	2.52	2.57
MRT (h)	0.47 (0.04)	0.47 (0.10)	0.76	0.72
V_d,ss (mL)	417 (98)	422 (124)	802	766
CL (mL·h⁻¹)	869 (132)	892 (120)	1050	1029

In female rats, concentrations were obtained from terminal sampling; therefore, individual profiles were not available, and SD could not be calculated.