Skip to main content
. 2021 Jan 2;118(1):282–294. doi: 10.1093/cvr/cvaa343

Figure 5.

Figure 5

Hydralazine reduced ex vivo and in vivo MI size. (A) When compared to vehicle control (N=9), pre-treatment with hydralazine (N=9) reduced MI size expressed as % of left ventricular volume in the isolated perfused murine hearts subjected to global acute myocardial IRI. The top panel depicts representative images of a murine heart slices treated with either control vehicle or hydralazine. Scale bars are 5 mm. (B) When compared to control vehicle (N=4), treatment with hydralazine at the onset of reperfusion (N=6) reduced MI size expressed as a % of the AAR in the murine hearts subjected to in vivo regional acute myocardial IRI. The centre panel shows that the AAR was not different between treatment groups. The right panel depicts representative images of a murine heart slices treated with either control vehicle or hydralazine. Statistical analysis was performed using the Student’s t-test. Data are expressed as mean±SEM. **P=0.0083. ***P=0.0003. Scale bars are 5 mm.