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. 2021 Feb 9;118(1):169–183. doi: 10.1093/cvr/cvab044

Figure 5.

Figure 5

TgGRK5 mice showed increased late immune cell infiltration in the heart and chronic cardiac inflammation post-myocardial infarction. Representative images and quantification of CD45 (A), MPO (B), CD68 (C) and CD3 (D) stainings for remote area (RA) and infarct area of hearts from NLC and TgGRK5 mice at 8 weeks post-myocardial infarction (MI) (n = 8–10). Scale bar in white or black (100 μm). Arrowheads indicate positive staining. Insets show higher magnification at ×250. Flow-cytometric quantification of immune cells isolated from NLC and TgGRK5 hearts at 4 weeks post-MI (E–K) (n = 8 per group). Quantification of RT-PCR data showing fold change of NLC-Sham for IL-6, IL-1β, VCAM1, CCL2, (L–O) in left ventricular samples collected at 8-weeks post-surgery (n = 8–16). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. One-way ANOVA with Tukey’s post hoc test or t-test were used between groups.