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. 2021 Feb 9;118(1):169–183. doi: 10.1093/cvr/cvab044

Figure 7.

Figure 7

Cardiomyocyte-GRK5 deletion improved contractility, diminished early immune cell recruitment to the heart and increased survival rate post-myocardial infarction. Ejection fraction (EF) (A) and left ventricular internal diameter in diastole (LVIDd) (B) as measured by echocardiography at 0 (baseline), 4- and 8-weeks post-Sham operation or myocardial infarction (MI) in WT and GRK5cKO groups (n = 8–23). Measures of heart weight to body weight ratio (HW/BW) at 8 weeks post-surgery (C) (n = 20–24). Representative images and quantification of CD45 (D), MPO (E) and CD68 (F) stainings for remote area (RA) and border zone (BZ) of hearts from WT and GRK5cKO mice at 4-days post-MI. Scale bar in white or black (100 μm). Arrowheads indicate positive staining. Insets show higher magnification at ×250 (n = 6–13). Flow-cytometric quantification of immune cells isolated from WT and GRK5cKO hearts at 4 days post-MI (G–L) (n = 8 per group). Kaplan–Meier survival curves of Sham and MI groups (M) (n = 11–37). Log-rank (Mantel–Cox) test has been used between groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; #P < 0.0001 vs. WT-Sham and GRK5cKO-Sham. Two- or one-way ANOVA with Tukey’s post hoc test, or t-test were used between groups.