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. 2020 Nov 2;118(1):141–155. doi: 10.1093/cvr/cvaa311

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© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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PDGF-BB amplifies the pro-inflammatory properties induced by oligomeric S100A4. EdgeR analysis of RNA sequencing data represented with Venn diagrams showing the total number and relations of down-regulated (A) or up-regulated (B) genes in S-SMCs after treatments with PDGF-BB, oS100A4, or PDGF-BB/oS100A4 for 4 h and histograms showing the fold-changes vs. the control conditions for EGR3 (C), GM-CSF (D), and CCL1 (E). Note that PDGF-BB amplifies oS100A4-induced up-regulation of GM-CSF (D) and CCL1 (E) is exclusively expressed after PDGF-BB/oS100A4 treatment. The fold-change and the Benjamini–Hochberg corrected P-value thresholds were set to 2 and 0.05, respectively. Experiment was performed with biological triplicates.