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OGTT和IRT：非黑棘皮病及黑棘皮病患者不同总睾酮水平血糖曲线下面积、胰岛素曲线下面积变化
Changes of glucose and insulin area under the curve in OGTT and IRT in female NAN and AN patients with different total testosterone levels
| Group | Female NAN | Female AN | Male NAN | Male AN | |
| NAN quartile groupings of female (NAN, Q): NAN, Q1(TT 0.06-0.72 nmol/L); NAN, Q2(TT 0.73-1.20 nmol/L); NAN, Q3(TT 1.21-1.82 nmol/L); NAN, Q4(TT 1.86-10.20 nmol/L). AN quartile groupings of female (AN, Q): AN, Q1(TT 0.09-0.69 nmol/L); AN, Q2 (TT 0.76-1.16 nmol/L); AN, Q3(TT 1.22-1.83 nmol/L); AN, Q4(TT 1.86-6.86 nmol/l). NAN quartile groupings of male (NAN, Q): NAN, Q1(TT 0.10-6.40 nmol/L); NAN, Q2(TT 6.50-9.30 nmol/L); NAN, Q3(TT 9.50-12.00 nmol/L); NAN, Q4(TT 12.20-44.40 nmol/L). AN quartile groupings of male (AN, Q): AN, Q1(TT 0.16-6.20 nmol/L); AN, Q2(TT 6.46-9.20 nmol/L); AN, Q3(TT 9.40-12.10 nmol/L); AN, Q4(TT 12.20-18.00 nmol/L). AUC-GLU: Area under the glucose curve; AUC-INS: Area under the insulin curve. Compared with Q1 in female and compared with Q4 in male, aP < 0.05, bP < 0.01. Compared with NAN quartile groupings, cP < 0.05, dP < 0.01. NAN: Non-acanthosis nigrican; AN: Acanthosis nigrican. | |||||
| n | 227 | 137 | 146 | 129 | |
| Age (year) | 30.76±7.62 | 28.37±6.84 | 32.23±9.12 | 28.26±6.43 | |
| AUC-GLU | |||||
| Q1 | 1330.50 (1150.88, 1487.25) |
1360.50 (1162.50, 1656.00) |
1508.48 (1251.75, 1913.63) |
1363.50 (1248.00, 1527.00) |
|
| Q2 | 1359.00 (1211.25, 1665.75) |
1536.00 (1296.00, 1861.50) |
1315.50 (1149.75, 1818.83) |
1296.00 (1172.63, 1536.38) |
|
| Q3 | 1426.50 (1234.88, 1635.00) |
1386.00 (1216.50, 1666.50) |
1267.50 (1149.75, 1522.50) |
1284.00 (1160.25, 1493.63) |
|
| Q4 | 1363.50 (1195.50, 1602.75) |
1436.25 (1266.00, 1997.25) |
1359.00 (1152.00, 1667.25) |
1410.75 (1253.63, 1738.50) |
|
| AUC-INS | |||||
| Q1 | 13957.50 (7656.98, 20330.44) |
23764.35 (19523.85, 33825.75) |
25165.73 (12962.70, 41568.04)a |
29333.85 (20074.95, 54597.45) |
|
| Q2 | 14267.10 (11581.20, 20473.65) |
25332.30 (14434.35, 37295.55)d |
17451.75 (11915.33, 28974.38) |
30970.95 (23208.15, 43562.25)c |
|
| Q3 | 22321.88 (13699.80, 34919.06)a |
26423.25 (20947.95, 34587.15) |
17622.90 (10012.91, 25435.61) |
22172.03 (17858.81, 30523.80)c |
|
| Q4 | 22240.13 (17265.94, 40798.43)b |
24933.15 (20305.73, 34210.13) |
15534.83 (11214.49, 23350.80) |
21397.13 (13059.49, 37083.53)c |
|