Table 2.

Simulation statistics for the estimated overall exposure effects on RMST for interval-censored survival data with moderate right censoring proportion (35%-45%) in the presence of a cured fraction.

Scenario‡	True	FP or RCS Parametric Approximation†					Piecewise Linear Approximation†
		Ave Bias	Ave PE (%)	SD of Est	AVE SE	CP (%)	Ave Bias	Ave PE (%)	SD of Est	AVE SE	CP (%)
n = 100 per group
1	0.461	0.009	2.0	0.400	0.385	94.3	0.007	1.5	0.403	0.382	93.3
2	0.458	0.002	0.4	0.400	0.391	95.1	0.003	0.5	0.401	0.386	95.1
3	0.480	0.009	1.8	0.360	0.361	95.8	0.008	1.7	0.36	0.356	94.7
4	0.526	−0.011	−2.1	0.373	0.359	94.9	0.004	0.8	0.382	0.365	93.4
5	0.446	0.013	2.9	0.400	0.388	94.5	0.010	2.3	0.398	0.382	94.1
6	0.462	0.006	1.5	0.426	0.409	94.0	0.004	1.0	0.427	0.405	93.4
7	0.465	−0.015	−3.2	0.411	0.424	96.0	−0.020	−4.3	0.413	0.420	95.5
8	0.463	−0.014	−2.9	0.395	0.390	94.0	−0.016	−3.3	0.396	0.386	93.6
n = 250 per group
1	0.473	−0.001	−0.1	0.256	0.251	95.0	0.001	0.3	0.256	0.251	94.7
2	0.47	0.001	0.2	0.267	0.254	95.2	−0.002	−0.4	0.266	0.255	95.5
3	0.491	−0.003	−0.6	0.241	0.236	94.7	0	0	0.242	0.235	93.2
4	0.541	−0.008	−1.4	0.242	0.241	95.4	−0.006	−1.1	0.240	0.241	96.0
5	0.458	0.004	1.0	0.249	0.251	94.8	0.002	0.5	0.248	0.250	95.0
6	0.473	0.003	0.7	0.270	0.266	94.6	0.001	0.2	0.271	0.266	94.1
7	0.475	−0.005	−1.0	0.279	0.274	94.3	−0.001	−0.2	0.277	0.272	93.2
8	0.475	−0.002	−0.5	0.261	0.253	94.6	−0.003	−0.6	0.260	0.252	94.8

^†: assessed at last observed time.

^‡: see section 4.1 (v) for the baseline hazard function specification of different simulation scenarios.