Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 11;5:21. doi: 10.1038/s42003-021-02986-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — The analysis workflow is composed of three main steps: (1) upload of user-provided data, containing predicted, pre-computed cell−cell interactions (CCI data); (2) exploration of three biological domains (so-called, universes), whereby the analysis focuses on cell clusters, genes, and biological functions; and (3) data-driven analysis through the definition and inspection of interaction-pair (int-pair) modules and the comparison of cell−cell communication from multiple conditions. For each step, filtering options (e.g., on cell clusters, genes, and functional databases) and multiple visualizations (e.g., networks, barplots, dotplots, circle plots, and sunburst plots) are provided to conduct a customized analysis. Moreover, all tables and figures can be saved in multiple formats, helping the interpretation of complex cell−cell interaction datasets and the finalization of publication-ready results.