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. 2022 Jan 11;5:21. doi: 10.1038/s42003-021-02986-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Differences in the total number of interactions per cell type are shown in back-to-back bar plots generated by InterCellar’s multiple conditions section. All interaction flows are considered (directed-outgoing: L-R pairs, directed-incoming: R-L pairs, and undirected: L-L and R-R pairs). Dots on the black curve represent differences between the number of interactions in critical compared to moderate cases. Both autocrine and paracrine interactions are considered and plotted separately in each bar. Cell types are automatically color-coded by InterCellar for consistency throughout the analysis. See Supplementary Data 1 for source data. b Relative differences in the number of interactions are displayed in the InterCellar multiple conditions section using radar plots, comparing moderate to critical cases. All interaction flows are considered. Each plot displays the number of interactions between a specific cell type and all other cell types participating in the communication, ordered alphabetically, counter-clockwise. Cell clusters belonging to the immune cell group are represented in the first row, while epithelial cell types are shown in the second row. Cell types can be grouped in (1) epithelial cells, namely basal, ciliated, ciliated-differentiating (ciliated-diff), FOXN4+, ionocyte, IFNG responsive cell (IRC), secretory, secretory-differentiating (secretory-diff) and squamous; and (2) immune cells, namely B cell, cytotoxic T cell (CTL), regulatory T cell (Treg), natural killer (NK), natural killer T cell (NKT), natural killer T cell-proliferating (NKT-p), neutrophil (Neu), plasmacytoid dendritic cell (pDC), monocyte-derived dendritic cell (moDC), mast cell (MC), resident macrophage (rMa), non-resident macrophage (nrMa) and monocyte-derived macrophage (MoMa).